These results demonstrate that measurement of blood viscosity during the coagulation process offers a number of potentially useful parameters. The MCV was significantly lower at a SR of 80 sec −1 versus 40 sec −1 ( P = 0.027) and the CLH significantly ( P = 0.048) increased for increasing SR. The TGP significantly ( P = 0.0023) shortened for increasing SR, and was significantly associated with the activated partial thromboplastin time at a SR of 20 sec −1 ( P = 0.038) and 80 sec −1 ( P = 0.019). On the basis of the time‐dependent changes in blood viscosity, we identified the gel point (GP), the time‐to‐gel point (TGP), the maximum clot viscosity (MCV), and the clot lysis half‐time (CLH). For each subject, three consecutive measurements were performed, at a SR of 20, 40, 80 sec −1. In this study, we investigated the viscosity changes of whole blood in 10 subjects with a normal coagulation profile, using a cone‐on‐plate viscosimeter. These changes are reflected by changes in blood viscosity however, blood viscosity at different shear rates (SR) has not been previously explored during the coagulation process. This correlation may be useful for anticipating the need for repeat plasmapheresis.During the coagulation process, blood changes from a liquid to a solid gel phase. Serum viscosity and electrophoresis are recommended before and after plasmapheresis in order to correlate viscosity and M-spike with patient symptoms. Hyperviscosity syndrome can also occur in multiple myeloma patients.īecause the ability of a monoclonal protein to cause hyperviscosity is affected by its concentration, molecular weight, and aggregation, sera with concentrations of monoclonal IgM greater than 4 g/dL, IgA greater than 5 g/dL, or IgG greater than 6 g/dL should be tested for hyperviscosity.

The most common cause of serum hyperviscosity is the presence of large concentrations of IgM monoclonal proteins, and Waldenstrom macroglobulinemia accounts for 80% to 90% of hyperviscosity cases. Funduscopic examination reveals dilation of retinal veins and flame shaped retinal hemorrhages. Hyperviscosity may be manifested by nasal bleeding, blurred vision, headaches, dizziness, nystagmus, deafness, diplopia, ataxia, paresthesias, or congestive heart failure.

Viscosity is the property of fluids to resist flow.

Blood viscosity test normal range